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Symbol
Name
ID

Gnai2
G protein subunit alpha i2
MGI:95772

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

abnormal cellular extravasation

abnormal leukocyte adhesion

increased T cell proliferation

increased susceptibility to induced colitis

large intestinal inflammation

colitis

peritoneal inflammation

increased thymocyte number

decreased eosinophil cell number

increased eosinophil cell number

increased neutrophil cell number

increased granulocyte number

abnormal leukocyte cell number

decreased T-helper 17 cell number

increased T cell number

increased single-positive T cell number

increased lymphocyte cell number

increased monocyte cell number

abnormal eosinophil physiology

abnormal neutrophil physiology

increased IgA level

increased IgG level

increased IgM level

increased immunoglobulin level

abnormal T cell physiology

increased circulating interferon-gamma level

increased circulating interleukin-4 level

increased circulating interleukin-5 level

abnormal cytokine level

abnormal immune system morphology

abnormal immune system physiology

abnormal cytokine secretion

increased interferon-gamma secretion

increased interleukin-1 beta secretion

increased interleukin-2 secretion

increased tumor necrosis factor secretion

increased inflammatory response

increased susceptibility to parasitic infection

Availability

Mouse Genotype

Gnai2^tm1Lbi/Gnai2^tm1Lbi

*!

!

!

Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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